You will find a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to lower afferent pain transmission and deliver analgesia. For that reason, drugs like clonidine that focus on alpha-2 receptors can affect the transmission of suffering. Applies to clonidine: https://rafaelanwld.wikiannouncing.com/6585960/onolidine_an_overview