Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators within the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, t... https://josefax010qhz0.wikicommunication.com/user