90% of ibuprofen is metabolised to inactive compounds during the liver, mainly by glucuronidation, to create two metabolites - a hydroxylated compound in addition to a carboxylated compound. Clear quantity of distribution is 0.14 L/kg. Ibuprofen and its metabolites easily cross the placental barrier in pregnant animals (rabbits and rats). https://marcelled568uqm6.cosmicwiki.com/user